Molecular biology

The exploration of the molecular mechanisms of life has always aroused interest within the scientific community. It is part of basic science but also provides an excellent platform for the development of biomedical sciences and industrial applications.

Our scientists specialise in molecular research, e.g. translational machinery, cellular transport, and identification and analysis of gene function and expression. They employ a plethora of modern genetic methods (e.g. high-throughput techniques) and protein bioengineering approaches.

1. Molecular genetics and bacterial genomics

  • Structural genomics (genomic sequencing and sequence annotation) of Legionella lytica - an unexplored etiological agent of legionellosis (Piotr Koper)
  • Genes pssV and regA as hypothetical elements of the signal transmission pathway in Rhizobium leguminosarum bv. trifolii (Kamil Żebracki)
  • Biosynthesis of bacterial exopolysaccharides: organisation and activity of the glycosyltransferase complex and mechanisms of biosynthesis regulation, e.g. the phosphorylation phenomenon in Rhizobium leguminosarum bv. trifolii (Małgorzata Marczak)

2. Regulation of the expression of genetic information at the translational level

  • Protein P phosphorylation versus regulation of ribosome response to stress (Kamil Filipek)
  • Role of phosphorylation of yeast elongation translation factor EF3 in interactions with the ribosome (Eliza Molestak)
  • Translation control in the Cancer European Network (Marek Tchórzewski)
  • Phosphorylation of ribosomal P proteins as a source of specialised ribosomes - a new level of regulation of gene expression in Eukaryotes (Marek Tchórzewski)
  • Search for extra-ribosomal partners of the uL10 protein in stress conditions (Barbara Michalec-Wawiórka)
  • Role of ribosomal P protein phosphorylation in interactions with the catalytic subunit of ricin (Przemysław Grela)
  • Ribosomal T-locus as a modulator of ribosome function in changing environmental conditions (Marek Tchórzewski)
  • Outside the translational cycle - the pleiotropic role of the L12 ribosomal protein (Leszek Wawiórka)

3. Regulation of amino acid transport via membrane amino acid transporters

  • Involvement of the trans-Golgi compartment in the regulation of the activity of amino acid transporters (Dawid Krokowski)

4. Spectroscopic and structural studies of the molecular organisation of biologically active compounds in model biological systems and the use of infrared microspectroscopy for chemical mapping at cell and tissue levels (Mariusz Gagoś, Agnieszka Dróżdż, Mirosława Bednarczyk, Katedra Biologii Komórki).

5. Interactions of flavonoids with model and natural membranes (Bożena Pawlikowska-Pawlęga, Justyna Kapral-Piotrowska)

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