Human and animal diseases

1. Investigation of mechanisms underlying the development of epilepsy and depression - search for treatment methods

  • Isolation of phenolic compounds contained in Zingiber officinale extracts and evaluation of their anticonvulsant activity in in vivo models ( Dorota Nieoczym)
  • Effect of SSR 504734, i.e. a selective inhibitor of type 1 glycine transporter, on the convulsive activity and therapeutic potential of selected anticonvulsants (Piotr Wlaź)

2. Mechanisms of anticancer activity of natural and synthetic bioactive substances

  • Assessment of the effect of alpha-ketoglutarate (AKG) on the level and activity of neutral endopeptidase (NEP) in cancer cells (Magdalena Mizerska-Kowalska)
  • Assessment of the anti-invasive activity of xanthohumol against lung cancer cells in vitro (Adrianna Sławińska-Brych)
  • Evaluation of the involvement of the Bcl-2 and Beclin-1 protein complex in elimination of glioma cells via programmed death (Adrian Zając)
  • Therapeutic potential of secondary metabolites from wood-degrading fungi in the treatment of cancer - biochemical and molecular mechanisms (Anna Matuszewska, Magdalena Jaszek, Dawid Stefaniuk)

3. Functionalisation of biomaterials

4. Fungi as a source of new agents that effectively modulate hemostasis processes (Dawid Stefaniuk)

5. The use of fungal metabolites in the fight against nematodes and other parasitic diseases (Anna Matuszewska, Magdalena Jaszek, Dawid Stefaniuk)

6. Investigation of the effectiveness and mechanisms of the fungicidal activity of selected 1,3,4-thiadiazole derivatives in interactions with azole and polyene antibiotics against strains with specific or multidrug resistance (Mariusz Gagoś)

7. Microscopic phytopathogenic fungi - biochemical characterisation and potential impact on the development of allergies in humans (Agnieszka Szuster-Ciesielska)

8. In vitro evaluation of mutual direct and indirect interactions between human corneal and conjunctival epithelial cells (Roman Paduch)

9. Effect of supplementation with amino acid derivatives and keto acids on proper development of cartilage and bone tissue (Piotr Dobrowolski)

10. Immunochemical analyses of Aeromonas sp. surface structures as polyvalent vaccine antigens (Anna Turska-Szewczuk)

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