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dr hab. Bożena Pawlikowska-Pawlęga

dr hab. Bożena Pawlikowska-Pawlęga
Position
Assistant Professor
Units
KATEDRA ANATOMII FUNKCJONALNEJ I CYTOBIOLOGII
Telephone number
81-5375991
E-mail address
Show
Consultation
Friday 11.00-13.00

Scientific Activity

Research focus

natural compounds-flavonoids and their derivatives, TEM, SEM,  membranes,  cancer and normal cells, NMR, FTIR, EPR, liposomes

Scientific interests

 As part of the biology discipline, I study the interactions of natural compounds and their derivatives with model and cell membranes, taking into account their interactions at the molecular level, structural and dynamic changes, and the orientation of the tested compounds in the membrane. Correlations of biophysical effects with biological effects on normal and cancer  cells, I investigate with application of : electron microscopy (SEM, TEM) and light techniques, immunocytochemistry at the level of cell ultrastructure, biophysical techniques, i.e. Fourier transform infrared absorption spectroscopy (FTIR), nuclear magnetic resonance (NMR) ) and electron paramagnetic resonance (EPR).

Professional education

Maria Curie-Skłodowska University in Lublin, Institute of Biology and Biochemistry,  Department of Functional Anatomy and Cytobiology, field: cell biology

  •    Assistant  Professor in biological sciences (2019)
  •    Doctor habilitatus in biological sciences (2015)
  •    Doctor degree in biological sciences (2003)
  •    MSc degree in biological sciences (1990)

Research projects

  1. Team Grant of the Vice-Rector of UMCS for Science Nr NB-14/2008 (2008) - project manager: Studies on the effects of apigenin and heat shock on human cervical cancer cells
  2. Project NCN No. 2014/13/B/ NZ/ 02106 (2015-2018) - main investigator: Characterization and significance of the novel oxalic acid oxidase (OXOAb) in Abortiporus biennis in response to the presence of heavy metals in the growth environment.

 

Awards  for scientific activity

  • UMCS Rector’s individual  award; 1999, 2001
  • UMCS Rector’s team award; 2010, 2014
  • UMCS Rector's awards for high - score article (3): 2020
Foreign and domestic  internships
1. Plant Agricultural University, Wageningen, The Netherlands, 16.11.1992-29.11.1992
2. Institute of Physics, Lublin, Poland, Department of Biophysics, Maria Curie-Skłodowska University, 1.09 2009-30.09.2009
3. Institute of Physics, Lublin, Poland, Department of Biophysics, Maria Curie-Skłodowska University,  1.09 2009-30.09.2011


 Recent papers

  1. Pawlikowska-Pawlęga B., Dziubinska H., Król E., Trębacz K., Jarosz-Wilkołazka A., Paduch R., Gawron A., Gruszecki W.I.: Characteristics of quercetin interactions with liposomal and vacuolar membranes. Biochimica et Biophysica Acta – Biomembranes, 2014, 1838, 254-265 
  2. Pawlikowska-Pawlęga B., Misiak L.E., Jarosz-Wilkołazka A., Zarzyka B., Paduch R., Gawron A., Gruszecki W.I.: Biophysical characterization of genistein-membrane interaction and its correlation with biological effecet on cells – The case of EYPC liposomes and human erythrocyte membranes. Biochimica et Biophysica Acta Biomembranes, 1838, 2014, 2127-2138
  3. Grąz M., Pawlikowska-Pawlega B., Jarosz-Wilkołazka A.: Intracellular distribution of cadmium during the growth of Abortiporus biennis on cadmium-amended media.  Canadian Journal of Microbiology, (2015), 61: 545-554
  4. Hułas-Stasiak M, Dobrowolski P, Pawlikowska-Pawlęga B, Tomaszewska E, Muszyński S  (2017). The effects of dexamethasone administered duringpregnancy on the postpartum spiny mouse ovary. PLoS One. 2017 Aug 21;12(8):e0183528. doi: 10.1371/journal.pone.0183528. eCollection 201     
  5. Bożena Pawlikowska-Pawlega,  Justyna Kapral,  Antoni Gawron, Anna Stochmal, Jerzy Zuchowski, Lukasz Pecio, Rafal Luchowski,  Wojciech Grudzinski, Wieslaw I. Gruszecki. (2018).  Interaction of a quercetin derivative - lensoside Aβ with liposomal membranes.  BBA -  Biomembranes 1860 (2018) 292-299
  6. Agnieszka Zdybicka-Barabas,  SylwiaStączek S.,BożenaPawlikowska-Pawlęga, Paweł Mak, Rafał Luchowski, Krzysztof Skrzypiec, Ewaryst Mendyk, Jerzy Wydrych, Wiesław I. Gruszecki, Małgorzata Cytryńska. (2019). Studies on the interactions of neutral Galleria mellonella cecropin D with living bacterial cells. Amino Acids 51: 175-191   
  7. Chudzik. B., Bonio K., Dąbrowski W., Pietrzak D., Niewiadomy A., Olender A., Pawlikowska-Pawlęga B., Gagoś M. Antifungal effects of a 1,3,4-thiadiazole derivative determined by cytochemical and vibrational spectroscopic studies. PLoS ONE, 14,9,2019, Article number e0222775
  8. Grela E., Zdybicka-Barabas A., Pawlikowska-Pawlęga B., Cytryńska M., Wlodarczyk M., Grudzinski W., Luchowski R., Gruszecki W.I. Modes of the antibiotic activity of amphotericin B against Candida albicans.Scientific Reports9,1, 2019, Article number 17029
  9. Grąz M., Jarosz-Wilkołazka A., Pawlikowska-Pawlega B., Janusz G., Kapral -Piotrowska J., Ruminowicz-Stefaniuk M., Skrzypek T., Zieba E. Oxalate oxidase from Abortiporus biennis – protein localisation and gene sequence analysis. International Journal of Biological Macromolecules  2020 Apr 1;148:1307-1315. 
  10. Szałapata, K., Osińska -Jaroszuk M., Kapral-Piotrowska J., Pawlikowska-Pawlęga B., Łopucki R., Mroczka R., Jarosz-Wilkolazka A. Serine protease inhibitors-new molecules for modification of polymeric biomaterials. Biomolecules, 10,1, 2020, Article number 82
  11.  J. Polak, K. Wlizlo,R.Pogni, E. Petrici, M.Graz, K.Szalapata,  M. Osinska-Jaroszuk, J. Kapral-Piotrowska, B. Pawlikowska-Pawlega, A. Jarosz-Wilkolazka. Structurte and biaoctive properties of novel textile dyes synthesissed by fungal laccase. Int J Mol Sci. 2020 Mar; 21(6): 2052.
  12. Sowa-Jasiłek, A., Zdybicka-Barabas, A., Stączek,  Bożena Pawlikowska-Pawlęga Katarzyna Grygorczuk-PłanetaKrzysztof SkrzypiecWiesław I. GruszeckiPaweł Mak  and Małgorzata Cytryńska Antifungal activity of anionic defense peptides: Insight into the action of galleria mellonella anionic  peptide 2. 2020 International Journal of Molecular Sciences 21(6):2052

 




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