Jednostki i pracownicy - książka adresowa

dr Arkadiusz Czerwonka

Stanowisko
adiunkt
Jednostki
KATEDRA WIRUSOLOGII I IMMUNOLOGII
Adres e-mail
Wyświetl

O sobie

RESEARCH FOCUS

My research activity is focused on natural and synthetic anticancer compounds and their role in intracellular signals transduction. I am interested in cancer cell biology, apoptosis-related events, cell cycle progression and topics connected with diet and chemoprevention.

Education:

  • PhD Fellowship at Maria Curie-Sklodowska University, Department of Virology and Immunology, Lublin, 2015. Thesis: “Evaluation of anticancer activity of selected 1,3-thiazine derivatives in colon carcinoma cell culture model”
  • M.Sc. in Microbiology, Maria Curie-Sklodowska University, Lublin, 2011. Thesis: “Evaluation of kynurenic acid anticancer activity in lung carcinoma cell culture model”

Działalność naukowa

Work experience and academic achievements:

  • Member of Multi-Omics Research Group, https://www.multiomics.pl
  • Assistant Professor in the Department of Virology and Immunology at Maria Curie-Skłodowska University. 2018 - until now
  • Research Assistant in the Department of Virology and Immunology at Maria Curie-Skłodowska University. 2015 - 2018
  • Co-Investigator position (contract of specified task - Western blot and zymography analysis) in research project granted by the Polish National Science Centre, titleed: „Influence of colon cancer cells soluble factors on macrophages differentiation” (grant no. 2013/09/D/NZ6/02564). 2014 - 2015
  • Group Awards of Rector of Maria Curie-Sklodowska University in Lublin. For year: 2019, 2018, 2017
  • Co-author of "Cell and tissue culture - practicum". Coursebook for students edited by Prof. dr hab. Roman Paduch. ISBN: 97883-227-9243-8. 2019
  • Main executor of the "Second Forum of Young Scientists - Innovativeness - Interdisciplinarity - Interactivity", organized by the Maria Curie-Skłodowska University and the Marshal Office of the Voivodeship in Lublin and in cooperation with the Institute of Agrophysics of the Polish Academy of Sciences in Lublin. 14-15.11.2018
  • Organization and conduct of cyclical events promoting UMCS and the Faculty of Biology and Biotechnology "The Night of Biologists" and "Open Door Day". 2015-20
  • Patent application „High-molecular protein-sugar fraction isolated from Dendrobaena veneta earthworm celomatic fluid for application in treatment of large intestine cancer” applicated by Arkadiusz Czerwonka, Marta Fiołka, Wojciech Rzeski (application number P.425431). 2018

Training courses:

  • „Optimize your RNA workflow-hints and pitfalls of RT-qPCR”. Promega 19.03.2019 Lublin, Poland
  • "Training in the use of a flow cytometer BD FACSAria TM II BD FACSDiva TM, Software Ver. 6.2.1". BD Biosciences 31.03.2017, Lublin, Poland
  • "For persons responsible for planning and carrying out procedures and experiments, performing procedures and killing animals used in procedures". Polish Society for the Study of Laboratory Animals, PolLASA 22-26.02.2016, Bydgoszcz, Poland
  • "The use of flow cytometry in the study of red blood cells". Center of Postgraduate Medical Education, Clinical-Didactic Study, 15-16.02.2016, Warsaw, Poland

International conferences

XI Parnas Conference – Young Scientists Forum. Biochemistry and Molecular Biology for Innovative Medicine. 3-5.09.2018, Kyiv, Ukraine, Posters:

  • Czerwonka A., Mizerska-Kowalska M., Musiał K., Zdzisińska B., Rzeski W., Fiołka M. J. "In Vitro studies on anticancer and antiviral properties of a high molecular weight fraction isolated from coelomic fluid of earthworm Dendrobaena veneta"
  • Okła K, Wawruszak A, Surówka J, Grąszczak A, Czerwonka A, Kaławaj K, Kotarski J, Wertel I. "Assessment of the clinicopathological relevance of mesothelin level in plasma, peritoneal fluid and tumor tissue of epithelial ovarian cancer patients"

IX Congreso Latinoamericano Micología. 22-25.08.2017, Lima, Peru, Poster:   

  • Kaczor J, Czerwonka A, Wawruszak A, Lemieszek MK, Rzeski W. „Comparison of anticancer properties of water, ethanol and ether extracts from Piptoporus betulinus (Fomitopsis betulina) collected in Poland and USA”

Sixth International Conference: Cancer Immunotherapy and Immunomonitoring (CITIM 2019). 29.04 - 02.05. 2019. Tbilisi, Georgia, Poster:

  • Okła K, Czerwonka A, Wawruszak A, Bobiński M, Pawłowska A, Suszczyk D. Bilska M, Tarkowski R, Bednarek W, Wertel I, Kotarski J. "Clinical Relevance and Immunosuppressive Pattern of Circulating and Infiltrating Subsets of Myeloid-Derived Suppressor Cells (MDSCs) in Epithelial Ovarian Cancer"

PUBLICATIONS

  1. Czerwonka A, Maciołek U, Kałafut J, (...), Kuźniar A, Rzeski, W. Anticancer effects of sodium and potassium quercetin-5′-sulfonates through inhibition of proliferation, induction of apoptosis, and cell cycle arrest in the HT-29 human adenocarcinoma cell line. Bioorganic Chemistry. 2020. 94,103426. doi: 10.1016/j.bioorg.2019.103426
  2. Czerwonka A, Wiater A, Komaniecka I, (...), Rzeski W, Pleszczyńska M. Antitumour effect of glucooligosaccharides obtained via hydrolysis of α-(1 → 3)-glucan from Fomitopsis betulina. Molecular Biology Reports. 2019. 46(6), pp. 5977598. doi: 10.1007/s11033-019-05032-x
  3. Sławińska-Brych A, Zdzisińska B, Czerwonka A, Mizerska-Kowalska M, Dmoszyńska-Graniczka M, Stepulak A, Gagoś M. Xanthohumol exhibits anti-myeloma activity in vitro through inhibition of cell proliferation, induction of apoptosis via the ERK and JNK-dependent mechanism, and suppression of sIL-6R and VEGF production. Biochim Biophys Acta Gen Subj. 2019 Aug 3;1863(11):129408. doi: 10.1016/j.bbagen.2019.08.001.
  4. Mizerska-Kowalska M, Kreczko-Kurzawa J, Zdzisińska B, Czerwonka A, Sławińska-Brych A, Maćkiewicz Z, Nidzworski D, Kandefer-Szerszeń M. Neutral endopeptidase (NEP) inhibitors - Thiorphan, sialorphin, and its derivatives exert anti-proliferative activity towards colorectal cancer cells in vitro. Chem Biol Interact. 2019 May 1. pii: S0009-2797(18)31165-7. doi: 10.1016/j.cbi.2019.04.033.
  5. Okła K, Czerwonka A, Wawruszak A, Bobiński M, Bilska M, Tarkowski R, Bednarek W, Wertel I, Kotarski J. Clinical Relevance and Immunosuppressive Pattern of Circulating and Infiltrating Subsets of Myeloid-Derived Suppressor Cells (MDSCs) in Epithelial Ovarian Cancer. Front. Immunol. 10 (2019) 1–13. doi:10.3389/fimmu.2019.00691.
  6. Okła K, Surówka J, Frąszczak K, Czerwonka A, Kaławaj K, Wawruszak A, Kotarski J, Wertel I. Assessment of the clinicopathological relevance of mesothelin level in plasma, peritoneal fluid, and tumor tissue of epithelial ovarian cancer patients. Tumor Biology. October 15, 2018 https://doi.org/10.1177/1010428318804937
  7. Czerwonka A, Lemieszek MK, Karpińska M, Matysiak J, Niewiadomy A, Rzeski W. Evaluation of the effect of 2-(2,4-dihydroxyphenyl)-4H-benzofuro[3,2-d][1,3]thiazin-4-one on colon cells and its anticancer potential. Medicinal Chemistry Research. 2018 July 17 doi: 10.1007/s00044-018-2223-8.
  8. Czerwonka A, Kaławaj K, Sławińska-Brych A, Lemieszek MK, Bartnik M, Wojtanowski KK, Zdzisińska B, Rzeski W. Anticancer effect of the water extract of a commercial Spirulina (Arthrospira platensis) product on the human lung cancer A549 cell line. Biomed Pharmacother. 2018 Jun 28;106:292-302. doi: 10.1016/j.biopha.2018.06.116.
  9. Lemieszek MK, Stepulak A, Sawa-Wejksza K, Czerwonka A, Ikonomidou C, Rzeski W. Riluzole Inhibits Proliferation, Migration and Cell Cycle Progression and Induces Apoptosis in Tumor Cells of Various Origins. Anticancer Agents Med Chem. 2018 Feb 28. doi: 10.2174/1871520618666180228152713.
  10. Czerwonka A, Kawka K, Cykier K, Lemieszek MK, Rzeski W. Evaluation of anticancer activity of water and juice extracts of young Hordeum vulgare in human cancer cell lines HT-29 and A549. Ann Agric Environ Med. 2017 Jun 12;24(2):345-349. doi: 10.26444/aaem/74714. Epub 2017 May 27
  11. Wawruszak A, Czerwonka A, Okła K, Rzeski W. Anticancer effect of ethanol Lycium barbarum (Goji berry) extract on human breast cancer T47D cell line. Nat Prod Res. 2016 Sep;30(17):1993-6. doi: 10.1080/14786419.2015.1101691. Epub 2015 Nov 2.